TABLE 5.

Sequence- and structural-based databases (ML approach).

Type	Brief introduction	URL	References
ProMate(Str)*	Circling of surface residues and Possible estimation of the binding affinity in each selected residues	bioinfo41.weizmann.ac.il/promate/promate.html	Neuvirth et al., 2004
WHISCY	It is a versatile server that is capable to use sequence and structure and its function is measurement of similarity score based on Dayhoff matrix	http://nmr.chem.uu.nl/Software/whiscy/	de Vries et al., 2006
PINUP(Str)*	Presentation of scoring function such as conservation score	http://sysbio.unl.edu/services/PINUP/	Liang et al., 2006
PIER(Str)*	Recognition of interfacial & un-interfacial surface residues	http://abagyan.ucsd.edu/PIER/	Kufareva et al., 2007
SPPIDER (Str)*	Identification of measured (RSA)* and real (RSA)	http://sppider.cchmc.org/	Porollo and Meller, 2007
PSIVER(Seq)*	Detection of binding sites between two proteins via Naïve Bayes and PSSM	http://tardis.nibio.go.jp/PSIVER/	Murakami and Mizuguchi, 2010

(Str)*, structure; (Seq)*, sequence; (RSA)*, relative solvent accessibility.