TABLE 2.
Significantly up- and downregulated serum proteins in SMI: Mod group rats.
| Accession | Description | Coverage | Unique peptides | Average folds SMI/Mod | p-value |
|---|---|---|---|---|---|
| D3ZJW6 | RCG21066, GN = rCG_21,066 | 9.40 | 1 | 1.59 | 0.0285 |
| A0A0G2K9Z5 | Uncharacterized protein | 9.32 | 1 | 1.56 | 0.0284 |
| Q5M871 | Fas apoptotic inhibitory molecule 3, GN = Fcmr | 4.23 | 1 | 1.43 | 0.0343 |
| M0RD98 | Uncharacterized protein | 6.56 | 1 | 1.33 | 0.0481 |
| Q5M8C6 | Fibrinogen-like protein 1, GN = Fgl1 | 15.92 | 6 | 1.32 | 0.0082 |
| A0A0G2K7P6 | Uncharacterized protein | 36.17 | 3 | 1.30 | 0.0076 |
| P15650 | Long-chain specific acyl-CoA dehydrogenase, mitochondrial, GN = Acadl | 5.81 | 2 | 1.29 | 0.0429 |
| P21743 | Insulin-like growth factor–binding protein 1, GN = Igfbp1 | 5.15 | 2 | 1.29 | 0.0124 |
| G3V8L7 | Integrin alpha M, GN = Itgam | 0.61 | 1 | 1.24 | 0.0128 |
| Q4KM75 | CD5 antigen-like, GN = Cd5l | 39.60 | 17 | 1.22 | 0.0492 |
| Q3T1H9 | Similar to Rnf37-pending protein, GN = Ubox5 | 1.86 | 1 | 1.21 | 0.0106 |
| A0A0G2K093 | Heat-shock 70-kDa protein 13, GN = Hspa13 | 3.01 | 1 | 1.21 | 0.0379 |
| D4AA05 | Carboxylic ester hydrolase, GN = Ces1a | 3.20 | 1 | 1.21 | 0.0377 |
| Q63514 | C4b-binding protein alpha chain, GN = C4bpa | 34.41 | 21 | 1.21 | 0.0328 |
| A0A0G2K0Q7 | Myosin light-chain kinase, GN = Mylk | 1.74 | 3 | 0.83 | 0.0416 |
| G3V7V8 | Phosphodiesterase, GN = Pde5a | 10.32 | 5 | 0.83 | 0.0436 |
| A0A096MK30 | Moesin, GN = Msn | 14.73 | 9 | 0.83 | 0.0338 |
| M0R5J4 | Uncharacterized protein | 37.56 | 10 | 0.83 | 0.0447 |
| M0R590 | Glyceraldehyde-3-phosphate dehydrogenase, GN = LOC108351137 | 25.83 | 5 | 0.83 | 0.0095 |
| P62963 | Profilin-1, GN = Pfn1 | 67.14 | 7 | 0.83 | 0.0339 |
| F1LQT3 | Rho-associated protein kinase, GN = Rock2 | 0.44 | 1 | 0.82 | 0.0207 |
| P18418 | Calreticulin, GN = Calr | 28.13 | 11 | 0.82 | 0.0340 |
| P07335 | Creatine kinase B-type, GN = Ckb | 22.83 | 6 | 0.82 | 0.0035 |
| Q7TPB1 | T-complex protein 1 subunit delta, GN = Cct4 | 2.04 | 1 | 0.82 | 0.0086 |
| P60711 | Actin, cytoplasmic 1, GN = Actb | 53.33 | 1 | 0.82 | 0.0218 |
| P45592 | Cofilin-1, GN = Cfl1 | 50.00 | 7 | 0.82 | 0.0399 |
| A0A0G2K8B7 | Eukaryotic initiation factor 4 A-II, GN = Eif4a2 | 2.21 | 1 | 0.82 | 0.0463 |
| Q9Z1P2 | Alpha-actinin-1, GN = Actn1 | 30.72 | 14 | 0.82 | 0.0387 |
| A0A0A0MXY5 | ATP-dependent 6-phosphofructokinase, GN = Pfkp | 2.00 | 1 | 0.81 | 0.0252 |
| Q62812 | Myosin-9, GN = Myh9 | 24.58 | 1 | 0.81 | 0.0006 |
| A0A0G2JZY6 | Spectrin beta chain, GN = Sptbn1 | 3.42 | 7 | 0.81 | 0.0097 |
| P0C5H9 | Mesencephalic astrocyte-derived neurotrophic factor, GN = Manf | 4.47 | 1 | 0.81 | 0.0150 |
| P10111 | Peptidyl-prolyl cis-trans isomerase A, GN = Ppia | 53.05 | 9 | 0.81 | 0.0093 |
| A0A0A0MY22 | Sialate O-acetylesterase, GN = Siae | 1.29 | 1 | 0.81 | 0.0196 |
| Q6AY18 | SAR1 gene homolog a (S. cerevisiae), isoform CRA_b, GN = Sar1a | 4.04 | 1 | 0.81 | 0.0484 |
| D4ACB8 | Chaperonin subunit 8 (theta) (predicted), isoform CRA_a, GN = Cct8 | 4.01 | 2 | 0.81 | 0.0045 |
| A0A0H2UHM7 | Tubulin alpha chain, GN = LOC100909441 | 33.26 | 3 | 0.80 | 0.0080 |
| P35213 | 14-3–3 protein beta/alpha, GN = Ywhab | 26.42 | 2 | 0.80 | 0.0013 |
| P85972 | Vinculin, GN = Vcl | 56.94 | 59 | 0.80 | 0.0291 |
| Q5XFX7 | RAD23 homolog a (S. cerevisiae), GN = Rad23a | 2.56 | 1 | 0.80 | 0.0067 |
| G3V6H0 | RAB1B, member RAS oncogene family like, GN = LOC100363782 | 11.94 | 1 | 0.80 | 0.0186 |
| Q4KM73 | UMP-CMP kinase, GN = Cmpk1 | 6.63 | 1 | 0.79 | 0.0204 |
| P68255 | 14-3–3 protein theta, GN = Ywhaq | 30.61 | 2 | 0.79 | 0.0092 |
| A0A0A0MY09 | Endoplasmin, GN = Hsp90b1 | 9.08 | 7 | 0.79 | 0.0403 |
| G3V852 | RCG55135, isoform CRA_b, GN = Tln1 | 44.51 | 95 | 0.79 | 0.0494 |
| Q99P74 | Ras-related protein Rab-27B, GN = Rab27 b | 5.05 | 1 | 0.79 | 0.0292 |
| P06302 | Prothymosin alpha, GN = Ptma | 11.61 | 1 | 0.79 | 0.0123 |
| Q7M052 | Alpha-1-macroglobulin | 12.50 | 1 | 0.79 | 0.0092 |
| Q9WUD9 | Proto-oncogene tyrosine-protein kinase src, GN = Src | 4.66 | 3 | 0.78 | 0.0404 |
| G3V8R1 | Nucleobindin 2, isoform CRA_b, GN = Nucb2 | 2.62 | 1 | 0.78 | 0.0425 |
| P68035 | Actin, alpha cardiac muscle 1 OS = Rattus norvegicus, GN = Actc1 | 44.30 | 4 | 0.78 | 0.0107 |
| Q08163 | Adenylyl cyclase–associated protein 1, GN = Cap1 | 38.61 | 14 | 0.77 | 0.0239 |
| P68511 | 14-3–3 protein eta, GN = Ywhah | 44.72 | 6 | 0.77 | 0.0287 |
| Q5XFX0 | Transgelin-2, GN = Tagln2 | 71.36 | 11 | 0.77 | 0.0299 |
| Q5RKI0 | WD repeat-containing protein 1, GN = Wdr1 | 19.80 | 11 | 0.77 | 0.0076 |
| P05370 | Glucose-6-phosphate 1-dehydrogenase, GN = G6pdx | 9.51 | 5 | 0.77 | 0.0355 |
| B2GVB9 | Fermitin family member 3, GN = Fermt3 | 23.91 | 14 | 0.77 | 0.0293 |
| M0R8A4 | Microtubule-associated protein RP/EB family member 2, GN = Mapre2 | 18.22 | 3 | 0.77 | 0.0316 |
| Q62636 | Ras-related protein Rap-1b, GN = Rap1b | 32.07 | 7 | 0.77 | 0.0222 |
| D4A901 | Bai1-associated protein 2-like 2, GN = Baiap2l2 | 1.15 | 1 | 0.76 | 0.0192 |
| Q4KM33 | Pleckstrin, GN = Plek | 37.71 | 10 | 0.76 | 0.0332 |
| Q91ZN1 | Coronin-1a, GN = Coro1a | 23.43 | 11 | 0.76 | 0.0064 |
| A0A0G2JWA2 | Phosphoinositide phospholipase C, GN = Plcg2 | 0.71 | 1 | 0.76 | 0.0185 |
| G3V6S3 | Calumenin, GN = Calu | 11.75 | 3 | 0.75 | 0.0022 |
| D4A7U1 | Zyxin, GN = Zyx | 6.74 | 3 | 0.75 | 0.0102 |
| Q923Z2 | Tropomyosin 1, alpha, isoform CRA_a, GN = Tpm1 | 31.34 | 3 | 0.75 | 0.0229 |
| Q5XI73 | Rho GDP-dissociation inhibitor 1, GN = Arhgdia | 32.84 | 7 | 0.74 | 0.0232 |
| F1M8F4 | Glia maturation factor gamma, GN = Gmfg | 9.86 | 1 | 0.74 | 0.0259 |
| A0A0G2QC04 | Plastin 1, GN = Pls1 | 9.37 | 4 | 0.73 | 0.0026 |
| D3ZRX9 | Calponin, GN = Cnn2 | 3.64 | 1 | 0.73 | 0.0256 |
| C0JPT7 | Filamin A, GN = Flna | 36.98 | 75 | 0.73 | 0.0329 |
| P63259 | Actin, cytoplasmic 2, GN = Actg1 | 53.33 | 1 | 0.73 | 0.0092 |
| P63086 | Mitogen-activated protein kinase 1, GN = Mapk1 | 1.96 | 1 | 0.73 | 0.0475 |
| P63102 | 14-3–3 protein zeta/delta, GN = Ywhaz | 55.10 | 7 | 0.73 | 0.0175 |
| B0BNA5 | Coactosin-like protein, GN = Cotl1 | 52.11 | 7 | 0.73 | 0.0277 |
| G3V9N0 | Polyadenylate-binding protein, GN = Pabpc4 | 0.93 | 1 | 0.73 | 0.0131 |
| G3V637 | Syntaxin-binding protein 2, isoform CRA_b, GN = Stxbp2 | 1.68 | 1 | 0.72 | 0.0034 |
| B2GUZ5 | F-actin-capping protein subunit alpha-1, GN = Capza1 | 5.24 | 1 | 0.72 | 0.0052 |
| A0A0G2K6J5 | Myosin light polypeptide 6, GN = Myl6 | 51.66 | 6 | 0.72 | 0.0141 |
| M0R979 | Thrombospondin 1, GN = Thbs1 | 52.36 | 1 | 0.71 | 0.0193 |
| F1M8L1 | Kinesin-like protein, GN = Kif2a | 1.14 | 1 | 0.71 | 0.0212 |
| Q9Z270 | Vesicle-associated membrane protein-associated protein A, GN = Vapa | 6.83 | 1 | 0.71 | 0.0053 |
| Q68FR2 | Bridging integrator 2, GN = Bin2 | 24.85 | 11 | 0.71 | 0.0447 |
| A0A0G2JU07 | Ubiquitin-conjugating enzyme E2 variant 2, GN = Ube2v2 | 6.90 | 1 | 0.71 | 0.0025 |
| Q8K3G3 | Four and a half LIM domains 1, isoform CRA_e, GN = Fhl1 | 3.81 | 1 | 0.71 | 0.0068 |
| P85515 | Alpha-centractin, GN = Actr1a | 3.46 | 1 | 0.69 | 0.0163 |
| D3ZSL2 | ABRA C-terminal-like, GN = Abracl | 30.86 | 2 | 0.68 | 0.0169 |
| F7EWA3 | SP140 nuclear body protein, GN = Sp140 | 0.91 | 1 | 0.68 | 0.0370 |
| P09495 | Tropomyosin alpha-4 chain, GN = Tpm4 | 59.68 | 8 | 0.67 | 0.0242 |
| Q4V7E8 | Leucine-rich repeat flightless-interacting protein 2, GN = Lrrfip2 | 2.06 | 1 | 0.67 | 0.0163 |
| Q66H98 | Serum deprivation-response protein, GN = Sdpr | 5.76 | 3 | 0.66 | 0.0068 |
| A0A0A0MY01 | Fatty acid-binding protein, intestinal, GN = Fabp2 | 6.06 | 1 | 0.66 | 0.0181 |
| P0DP31 | Calmodulin-3, GN = Calm3 | 30.20 | 4 | 0.65 | 0.0119 |
| D3ZVU2 | FANCD2 and FANCI-associated nuclease 1, GN = Fan1 | 0.69 | 1 | 0.65 | 0.0404 |
| G3V6P7 | Myosin, heavy polypeptide 9, nonmuscle, GN = Myh9 | 24.44 | 1 | 0.63 | 0.0278 |
| B0BMS8 | Myl9 protein, GN = Myl9 | 31.40 | 1 | 0.62 | 0.0230 |
| D3ZGX9 | Sema domain, immunoglobulin domain (ig), short basic domain, secreted (semaphorin), 3 F (predicted), isoform CRA_a, GN = Sema3f | 0.76 | 1 | 0.61 | 0.0127 |
| F7EWC1 | Vasodilator-stimulated phosphoprotein, GN = Vasp | 5.88 | 2 | 0.58 | 0.0046 |
| A0A0G2JSW0 | Myosin regulatory light chain 12B, GN = Myl12 b | 31.40 | 1 | 0.58 | 0.0167 |
| P49889 | Estrogen sulfotransferase, isoform 3, GN = Ste | 2.37 | 1 | 0.54 | 0.0072 |