TABLE 1.

Histone acetylation involved in the expression of vascular tone mediators.

Stimuli	Histone acetylation	HAT or HDAC involved	Targeting	References
Laminar shear stress	H3ac, H4ac	p300	eNOS (SSRE region)	Chen et al., 2008
Hypoxia	H2A.Zac, H3K9, H3K14, H4K5, H4K8, H4K12		eNOS	Fish et al., 2010
	H3ac, H4ac		eNOS	Xu et al., 2010
	H3K9ac, H2A.Zac		eNOS (STAT3 binding)	Postberg et al., 2015; Chao et al., 2018
Persistent pulmonary hypertension of newborn	H4K12ac		eNOS (Sp1 binding)	Ke et al., 2018
27nt small RNA	H3K9ac, H3K12ac, H3K23ac, H4K8ac, H4K12ac	HDAC3	eNOS	Zhang et al., 2008
DJ-1/park7	H3ac	HDAC1	eNOS	Won et al., 2014
Athero protective pulsatile shear stress	H3K27ac		ITPR3 (KLF4 binding)	He et al., 2019
Pathogenic factors of hypertension	H3K9ac	SIRT6	Nkx3.2	Guo et al., 2019
Pathogenic factors of heart failure	H3K56ac	SIRT3, p300	eNOS, arginase II	Su et al., 2020
Maternal nutrient restriction	H3K9ac, H3K18ac, H4ac		ET-1 (HIF-1a binding)	Xu et al., 2013
Shear stress	H3K14ac	CBP	c-fos, c-jun	Illi et al., 2003