TABLE 2.

Inflammation signals mediated by histone acetylation in ECs.

Stimuli	Histone acetylation	HAT or HDAC involved	Targeting	References
Dengue virus infection	H3ac, H4ac		IL-8	Bosch et al., 2002
Listeria monocytogenes infection	H4K8ac, H3K14ac	CBP	IL-8	Schmeck et al., 2005
	H4ac, H3K14ac		IL-8 (NF-κB/p65 binding)	Schmeck et al., 2006
Chlamydophila pneumoniae infection	H3ac, H4ac		Cytokines (p65/RelA binding)	Schmeck et al., 2008
Bach1	H3ac, H4ac	HDAC1	IL-8	Jiang et al., 2015
Integrin engagement	H3ac		ICAM-1, VCAM-1	Rose et al., 2005
TNF-α stimulus during blood vessel maturation	H3ac		E-selectin	Hamada et al., 2014
LDL	H3K9ac, H3K14ac		p66shc	Kim et al., 2012
oxLDL	H3K14ac, H4ac	CBP, p300, HDAC1, HDAC2	IL-8, MCP-1	Dje N’Guessan et al., 2009
Hyperglycemia or RAGE	H3K9ac		Cox2 (NF-κB binding)	Perrone et al., 2009
Lysophosphatidylcholine	H3K14ac		ICAM-1 (AP-1 binding)	Li X. et al., 2018; Lu et al., 2019
Angiotensin II	H3ac		CSF1	Shao et al., 2019
Tumor angiogenic growth factors	H3ac		ICAM-1	Hellebrekers et al., 2006
Estrogen	H3ac, H4ac	CBP	MHC II	Adamski et al., 2004
IL-1β	H3K27ac		Genomic sites occupied by NOTCH1-RBPJ	Poulsen et al., 2018
TNF-α	H3ac		Netrin-1	Passacquale et al., 2015
TNF-α or IL-1β	H3K27ac, H4ac	HDAC2	RNASE1	Bedenbender et al., 2019
Polychlorinated biphenyls	H3ac	p300, HADC1, HDAC2	IL-6, CRP, ICAM-1, VCAM-1, IL-1α, IL-1β	Liu et al., 2016
Epigallocatechin-3-gallate	H3K9ac, H3K14ac	HDAC5, HDAC7, p300, CBP	Chromatin relaxation	Ciesielski et al., 2020