TABLE 3.
Histone acetylation involved in endothelial mediated oxidative stress.
Stimuli | Histone acetylation | HAT or HDAC involved | Targeting | References |
Hyper glycemia | H3K9ac | SIRT1, SRC-1 | p66shc (p53 binding) | Zhou et al., 2011; Paneni et al., 2012; Costantino et al., 2019; Mishra et al., 2019 |
H2O2 | H3K14ac, H4K16ac | SIRT1 | p53 | Jamal et al., 2014 |
HDACi scriptaid | H4ac, H3K27ac | HDAC3 | Nox4 (c-jun binding) | Siuda et al., 2012 |
HDAC inhibitors | H3K27ac | SOD3 | Zelko and Folz, 2015 | |
Exendin-4 | H3ac | HDAC activity | SOD3 | Yasuda et al., 2016 |
CAPE | H3ac | HDAC1 | SOD3 (MEF2A binding) | Ohashi et al., 2017 |
Hyper glycemia | H3K9ac, H3K27ac | HDAC2 | SOD2 | Hou et al., 2018 |
Oxidative stress | H4K16ac | SIRT1 | Antioxidant genes (FoxO3a and PGC-1 binding) | Olmos et al., 2013 |