TABLE 4.
Histone acetylation associated with angiogenesis.
Stimuli | Histone acetylation | HAT or HDAC involved | Targeting | References |
Angiogenic signals | H3K56ac | CBP | VEGFR1 | Dutta et al., 2010 |
VEGF stimulation | H3ac | PCAF | VEGFR1, VEGFR2, ANGPT2 (E2F1 binding) | Pillai et al., 2010 |
VEGF stimulation | H3K27ac | p300 | Angiogenic genes | Zhang et al., 2013 |
SerRS | H4K16ac | SIRT2 | VEGFA (c-myc binding) | Shi et al., 2014 |
VEGF stimulation | H3K9ac, H3K14 ac, H4ac | p300 | VE-cadherin (SRF binding) | Shu et al., 2015 |
Osteoporosis (ZEB1 loss) | H3K4ac, H3K14ac, H3K18ac | p300, CBP | Dll4, NOTCH1 | Fu et al., 2020 |
NF-kB signal | H3ac, H4ac | p300, HDAC1 | cFLIP, NFAT | Aurora et al., 2010 |
CO | H3K9ac, H3K18ac, H3K23ac | HDAC3 (implied) | Angiogenic genes | Li et al., 2014 |
KAT7 KO | H3K14ac, H4ac | KAT7 | VEGFR2 | Yan et al., 2018 |
VEGF stimulation and HDAC inhibitors | H3K9ac | HDAC1 (implied) | Angiogenic genes | Jin et al., 2011 |
HDAC7 KO | H3ac | HDAC7 | AKAP12 | Turtoi et al., 2012 |