TABLE 5.

EC barrier function mediated by histone acetylation.

Stimuli	Histone acetylation	HAT or HDAC involved	Targeting	References
Hyperglycemia	H3K9ac		MMP-9 (p65 binding)	Zhong and Kowluru, 2013
	H3K9ac		Claudin-5, Claudin-11	Li et al., 2017
	H3K9ac, H3K14ac	p300, SIRT1	ET-1, TGF-β1	Mortuza et al., 2015
LPS	H3K9ac and H3K18ac		VE-cadherin	Thangavel et al., 2014
Scald injury	H3K9ac		VEGF, MPO	Tang et al., 2018
HDAC inhibitors	H3K9ac, H3K14ac		MDR1 (AHR binding)	You et al., 2019