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Fast dynamics of the N-SH2 and C-SH2 domains in their apo states and in complexes with phosphopeptides. S2 order parameters extracted from the fit of the 15N R1, R2 and heteronuclear NOE data to the Lipari-Szabo model-free parametrization of fast motions. A. S2 order parameters of N-SH2, N-SH2–ITIM and N-SH2–ITSM. B. S2 order parameters of C-SH2 and C-SH2–ITSM. The residue numbers are given on the x-axes. Secondary-structure elements are indicated along the sequence.
