Fig. 8.
CNA analysis of the MD simulations of N-SH2–pY, SB N-SH2–pY and C-SH2–pY. (A, B, C) Network centrality of the Cα atoms in N-SH2–pY (A), SB N-SH2–pY (B) and C-SH2–pY (C), respectively. The residues with the highest degree of centrality (hubs) are shown as spheres. The color-range from blue to red indicates the degree of betweenness centrality. (D, E, F) Representation of 250 communication pathways between three different regions of N-SH2–pY. Dynamic changes in the BC loop due to pY binding can be relayed to the EF (D) and BG (E) loops via the central β sheet, while αB mediates transfer of dynamic information between the EF and BG loops (F). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)