Table 2.

The effect of the signaling pathway of estrogen in vivo.

Model	Treatment	Function	Reference
Male C57BL/6 mice (6–8 weeks old)	Hyperthyroidism was induced by injecting TH	The livers from TH-treated mice had significantly more mitochondria in an ESRRA-dependent manner.	(32)
BALB/c nude female mice (4–6 weeks old)	K-1 (NTC and shERβ) cells were subcutaneously injected	The tumor volumes in shERβ-1 and shERβ-2 groups were apparently smaller than NTC group	(29)
PTEN mutant mice	Ovariectomy was performed on 4-week-old mice	Complete estrogen ablation reduced the proliferative index of female thyroids to the same levels observed in mutant males	(33)