Table 1.

Differences between mouse and human selectins.

	Human versus Mouse
E-selectin	Lectin domain homology: 72% (16)
	EGF domain homology 60% (17)
	Mice have a greater interdomain angle (more flexibility, better binding to sLex) (17)
	ESL-1 is not a functional E-selectin ligand in humans (18)
P-selectin	TNFa, IL1B and LPS increase P-selectin mRNA in mice but decrease it in humans (19)
L-selectin	Human E-selectin binds sLex on L-selectin (mouse L-selectin lacks fucosylation) (18)
	Fucosyltransferase 9 (FUT9) plays a key role in human L-selectin biosynthesis (20)