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Nicotine up-regulated the decreased MMP-9 expression in placentas from LPS-induced PE-like mice. Representative immunofluorescent images (A) and graph bar (B) showed changes in levels of MMP-9 immunoreactivity (green) in the trophoblast layer of placentas from all animal groups. Scale bar=50 μm. *P < 0.05 and **P < 0.01.
