FIGURE 5.

AEA alters miRNA expression in the mononuclear cells isolated from the lungs of SEB injected mice. Mice were treated with SEB and AEA as described in Figure 1 legend. Isolated mononuclear cells of the lung were screened for miRNA expression as described in methods (A). The heat map that shows all of the altered and unchanged miRNAs in the VEH + SEB and AEA + SEB groups. (B) Diagram of miRNAs with 1.5 fold change showing 59 miRNAs upregulated while 77 miRNAs downregulated. (C) Networking of the miRNAs with their targeted genes including anti-inflammatory genes, the map showing the main miRNAs including miRNA 23a-3p targeting ARG1 and TGFβ2 gene while miRNA 34a-5p targeting FOXP3 gene.