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Thermodynamic parameters for Mg2+ binding to mGCAP2 after fitting ITC data to a three-sequential binding site model (mean ± SD, n = 2)
| mGCAP2 Mg2+ titration (3-site model) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Apparent dissociation constant KD |
Enthalpy change ΔH (kcal/mol) |
Entropy change −TΔS (kcal/mol) |
||||||
| KD1 (μM) | KD2 (nM) | KD3 (μM) | ΔH1 | ΔH2 | ΔH3 | −TΔS1 | −TΔS2 | −TΔS3 |
| 0.72 ± 0.13 | 8.6 ± 0.7 | 10.2 ± 1.9 | 15.20 ± 0.14 | 0.02 ± 0.76 | 8.6 ± 0.8 | −23.6 ± 0.3 | −4.43 ± 0.10 | −15.4 ± 0.7 |
