Table 5.
Comparison of GC1 regulation by GCAP1 and GCAP2 variants
Protein | cGMP production (pmol/min) [n] |
|
---|---|---|
Low Ca2+ | High Ca2+ | |
Control | 1.14 ± 0.05 [2] | 1.12 ± 0.04 [2] |
mGCAP1 | 39.5 ± 3.8 [3] | 2.0 ± 0.5 [3] |
mGCAP2 | 4.6 ± 0.2 [2] | 4.3 ± 0.4 [2] |
nmGCAP2 | 6.2 ± 0.6 [3] | 6.0 ± 0.5 [3] |
G157R | 1.3 ± 0.1 [3] | 0.68 ± 0.03 [3] |
Data are reported as mean ± SD, and n represents the number of independent technical replicas.