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. 2021 May 1;24(5):102457. doi: 10.1016/j.isci.2021.102457

Figure 1.

Figure 1

TSPO is an indicator of the progression of NAFLD

(A) Immunohistochemistry staining showing TSPO levels in human liver paraffin sections (n = 3). The brown color indicates a positive TSPO signal (black arrow, left panel). After the removal of areas of blood and vessels by ImageJ software, quantification showed the TSPO positive signal in each field in normal, steatosis, NASH, and cirrhosis liver (right panel). Scale, 200μm.

(B) Immunofluorescence staining showing TSPO immunoreactivity signal in control (chow diet), steatosis, and NASH mouse models. The upper panels are low magnification, and the lower panels are high magnification of the selected dotted areas. Red colors indicate positive TSPO signal (white arrow). TSPO signals were quantified in control, steatosis, and NASH models. Scale, 40 μm.

(C) qPCR data showing Tspo/Gapdh relative mRNA expression in mouse liver of control, steatosis, and NASH (n = 3). Data are represented as mean ± SD, ∗p < 0.05, ∗∗p < 0.01 by one-way ANOVA.