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. 2021 May 1;24(5):102457. doi: 10.1016/j.isci.2021.102457

Figure 7.

Figure 7

Loss of TSPO reduced serum BAs and inflammation and ameliorated liver fibrosis

(A) Serum test of cholesterol, triglyceride, ALT, and total BAs in WT and TSPO KO after MCD feeding.

(B) Schematic summary of PCA in WT and TSPO KO with chow or MCD feeding.

(C) Heatmap of cluster marker genes in WT and TSPO KO with chow or MCD feeding.

(D) qPCR data showing relative mRNA levels of Tspo, Lgals1, Slc20a1, F4/80, Tlr4, Tnfa, Fxr, and Fgf21 versus Rps18 in WT and TSPO KO after MCD feeding.

(E) Immunoblot showing TSPO, ACTA2, CYP71A, CYP27A1, FXR, and TNFα after MCD feeding between WT and TSPO KO. Immunoblots were quantified by ImageJ.

(F) Sirius red staining showing collagen fiber (red color) distribution between WT and TSPO KO after chow and MCD feeding. Quantification of Sirius red staining. Scale, 400 μM. Data are represented as mean ± SD, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 by Student's t-test.