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. 2021 Apr 28;12:659943. doi: 10.3389/fimmu.2021.659943

Figure 4.

Figure 4

Treatment effects of lipid mediators in crude lung homogenate at the local site of intervention. (A) PGE3, (B) 9-HEPE, (C) 11-HEPE, (D) 12-HEPE, (E) 18-HEPE, (F) PD1, (G) PGD2 and (H) PGE2. All data are presented in pg/µL. All mice, except untreated controls, were on standard TB antibiotics Rifafour® for 4 days of treatment, then rifampicin and isoniazid (RH) for 10 days. All values represent mean ± SEM. Results repeated in two experiments, data shown for one experiment (n=6 per group). One-way ANOVA followed by Tukey’s post-hoc test was used to compare means, *P < 0.05, **P < 0.01 and ***P < 0.001. EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; HEPE, hydroxyeicosapentaenoic acid; PGD2, prostaglandin D2; PGE3, Prostaglandin E3; PD1, Protectin D1 and PGE2, prostaglandin E2; PT, post treatment; PI, post infection.