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. 2021 Apr 21;24(5):102459. doi: 10.1016/j.isci.2021.102459

Figure 2.

Figure 2

Schematic representation of TDP-43 protein and its truncation sites

For a Figure360 author presentation of Figure 2, see https://doi.org/10.1016/j.isci.2021.102459.

TDP-43 includes multiple cleavage sites encompassing its NLS (nuclear localizing signal), RNA-binding motifs (RRM1 or RRM2), and Glycine-rich domain. Colored circles represent cleavage type, while the numbers inside indicate the amino acid residue from the N-terminal end. TDP-35 lacks functional NLS, while TDP-25 lacks NLS along with functional RRM domains leading to splicing and RNA-binding abnormalities.