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TDP-43 fragments accumulate in various neurodegenerative disorders
Cytoplasmic accumulation of TDP-35 and TDP-25 CTFs can be found in primary (ALS and FTLD) and secondary (AD, CBD, PD, TBI) TDP-43 proteinopathies. Although TDP-43 pathology is also present in Huntington Disease and several Spinocerebellar ataxia (SCA) forms such as SCA2, SCA3 and SCA7, the presence of TDP-43 fragments in these polyglutamine disorders remain elusive.
