Table 3.
Animal models expressing truncated TDP-43
| CTF transgene | Model organism | Phenotypes and key characteristics | Reference |
|---|---|---|---|
| TDP-25 | Rat (Rattus) | Forelimb impairment | (Dayton et al., 2013) |
| TDP-25 | Mouse (Mus musculus) | Reduced motor function, impaired autophagy and proteasomal function | (Caccamo et al., 2015) |
| hTDP-25 | Fruit fly (Drosophila melanogaster) | Reduced longevity and locomotor function when expressed in motor neurons | (Gregory et al., 2012) |
| TDP-43CTF (~25 kDa) | “ | Reduced longevity and induced Caspase-3 activation when expressed in motor neurons | (Voigt et al., 2010) |
| Flag-TDP-35 | “ | Pupal lethality when expressed in the eye | (Crippa et al., 2016) |
| Flag-TDP-25 | “ | Mild disorganization of retinal structures when expressed in the eye | (Crippa et al., 2016) |
| TDP-25-YFP | Worm (Caenorhabditis elegans) | Protein aggregation and locomotor defects | (Zhang et al., 2011) |