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. 2021 Apr 28;12:590477. doi: 10.3389/fphar.2021.590477

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Copyright © 2021 Chen, Li, Hu, Wei and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduce effects of the main bioactive compounds of licorice on the PI3K/AKT/NFκB signaling pathway. The levels of PI3K, AKT and NF-κB proteins were detected by Western blotting(J). The relative expression of p-PI3K(A), p-AKT1(D), p-NFκB-p65(G) protein and ratio of p-PI3K/PI3K(B), p-AKT1/AKT1(E), p-NFκB-p65/NFκB-p65(H) and total PI3K(C), AKT1(F) and NFκB-p65/NFκB-p65(I) protein were quantified. Data are presented as the mean ± standard error of the mean (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.001 vs. Con group; #p < 0.05, ##p < 0.01, ###p < 0.001, ####p < 0.0001 vs. LPS group. Liquiritin apioside, LA; Liquiritigenin, LIQ; Isoliquiritin apioside, IA; Glycyrrhizin, GLY; LPS, lipopolysaccharide.