Table 2. Baseline Patient History and Quality of Life.
| Parameters | No. (%) of patients | |
|---|---|---|
| Usual care + antimicrobial therapy (n = 254) | Usual care (n = 259) | |
| FVC, No. | 247 | 255 |
| Median (IQR), L | 2.68 (2.14-3.23) | 2.73 (2.20-3.32) |
| Percent predicted, No. | 237 | 254 |
| Median (IQR) | 68.9 (56.7-81.8) | 71.17 (57.4-83.8) |
| FEV1, L, No. | 247 | 255 |
| Median (IQR) | 2.15 (1.76-2.64) | 2.23 (1.76-2.67) |
| Percent predicted, No. | 237 | 254 |
| Median (IQR) | 78.0 (64.1-92.2) | 77.2 (65.7-88.8) |
| FEV1:FVC, No. | 242 | 258 |
| Median (IQR) | 73.8 (72.3-75.1) | 73.5 (72.2-74.9) |
| FEV1:FVC <70%, No./total (%) | 13/242 (5.0) | 12/258 (5.0) |
| Dlco, No.a | 240 | 252 |
| Median (IQR), mL·min−1·mm Hg−1 | 10.74 (8.27-14.42) | 11.56 (8.74-14.73) |
| % Predicted, No. | 233 | 251 |
| Median (IQR) | 39.50 (29.32-48.61) | 38.37 (30.97-49.01) |
| GAP stage, No.b | 233 | 251 |
| I | 60 (25.8) | 54 (21.5) |
| II | 124 (53.2) | 133 (53.0) |
| III | 49 (21.0) | 64 (25.5) |
| Patient-reported parameters | ||
| Shortness of breath, No.c | 251 | 257 |
| Median (IQR) | 28.0 (11.0-51.0) | 30.0 (14.0-48.0) |
| EQ-5D-5Ld | ||
| Index, No. | 250 | 255 |
| Median (IQR) | 0.81 (0.73-1.00) | 0.81 (0.71-1.00) |
| Visual analog scale, No.e | 218 | 212 |
| Median (IQR) | 70.5 (54.0-88.0) | 75.00 (60.0-85.0) |
| ICECAP-O, No.f | 253 | 258 |
| Median (IQR) | 0.38 (0.18-0.52) | 0.40 (0.19-0.54) |
| Short Form Health Survey | ||
| 12-Item mental component, No.g | 252 | 258 |
| Median (IQR) | 54.8 (46.3-60.2) | 54.8 (48.9-59.9) |
| 12-item physical component, No.g | 251 | 258 |
| Median (IQR) | 40.4 (35.5-48.0) | 39.3 (34.2-46.5) |
| 6-item descriptive system, No.h | 249 | 258 |
| Median (IQR) | 0.72 (0.63-0.82) | 0.72 (0.66-0.80) |
| Fatigue severity scale, No.i | 252 | 253 |
| Median (IQR) | 3.89 (2.67-4.89) | 4.00 (2.67-5.22) |
| Leicester cough scale, No.j | 249 | 257 |
| Median (IQR) | 17.8 (14.4-19.8) | 18.3 (15.2-20.1) |
Abbreviations: Dlco, diffusing capacity of lung for carbon monoxide; FEV1, forced expiratory volume in the first second of expiration; FVC, forced vital capacity; IQR, interquartile range.
Corrected for hemoglobin by the coordinating center using the Cotes equation.17
The gender, age, physiology (GAP) index is a multidimensional scoring system that is associated with mortality in patients with IPF (higher scores indicate poorer prognosis).18
Score based on the University of California, San Diego, shortness of breath questionnaire (range, 0-120; higher values indicate worse shortness of breath).19
The 5-level EuroQol 5-dimension questionnaire (EQ-5D) quality-of-life score (range, −0.59 to 1; higher score indicates better health utility).20
Range, 0 to 100 (<70 are associated with frailty; higher scores indicate better health).20
ICEpop CAPability measure for Older people (ICECAP-O) summary score (range, 0-1; higher score indicates better well-being).21
Higher scoresindicate a better quality of life (range, 0-100).22
The 6-item descriptive system (SF6D) uses 6 of the SF-36 dimensions in economic evaluation studies (range, 0.29-1; higher score indicates better health).22
A 9-item scale with each item scored from 1 to 7 (higher score is worse).23
A cough-related quality-of-life score (range, 3-2; higher values represent better quality of life.)24