FIGURE 7.

Knockdown of MSI2 and SNORD12B with ZBTB4 overexpression suppressed tumor growth and prolonged survival in nude mice. (A) Subcutaneously xenografted nude mice injected with different treated cells are shown (above). Representative tumors from each group are shown (below). (B) Tumor growth curves are shown. Tumor size was recorded every 5 days, and tumors were extracted at 45 days after injection. **p < .01 versus control group; ^&& p < .01 versus MSI2(−) group; ^## p < .01 versus SNORD12B(−) group; ^ΔΔ p < .01 versus ZBTB4(+) group by one‐way ANOVA. (C) Survival curves of nude mice with orthotopic xenografts are shown. Data are presented as the mean ± SD of eight mice per group