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. Author manuscript; available in PMC: 2022 Feb 17.
Published in final edited form as: ChemMedChem. 2020 Nov 19;16(4):654–661. doi: 10.1002/cmdc.202000607

Table 2.

Recovery of meropenem susceptibility in E. coli MG1655 and UTI89 expressing NDM-1.

Treatment Meropenem MIC (μg/mL)
E. coli MG1655 E. coli UTI89
Meropenem alone 64 >64
Meropenem + 100 μM 5 4 ≤0.5
Meropenem + 100 μM 7 64 64
Meropenem + 100 μM 8 2 4
Meropenem + 100 μM 13 2 1
Meropenem + 25 μM 9 16 4–8[a]
Meropenem + 50 μM 9 1–4[a] ≤0.5
Meropenem + 100 μM 9 ≤0.5 ≤0.5
Meropenem + 200 μM 9 ≤0.5 ≤0.5
[a]

Ranges are given where differences were consistently observed between biological replicates.