. 2021 May 5;62(Suppl 1):i71–i77. doi: 10.1093/jrr/rraa096

Table 2.

Current hypothesis on crucial driver oncogenes in different etiologies and age groups

Age at diagnosis		Radiation-induced (Chernobyl)	Sporadic
5–10 years (Pediatric)	Initiating event frequency	Fusion	Very rare
5–10 years (Pediatric)	Importance in growth advantage	Fusion	Very rare
10–20 years (Adolescent)	Initiating event frequency	Fusion ≫ BRAF	Fusion < BRAF^a
10–20 years (Adolescent)	Importance in growth advantage	Fusion ≫ BRAF	Fusion ≫ BRAF
20+ years (adult)	Initiating event frequency	Fusion >? BRAF	Fusion ≪ BRAF
20+ years (adult)	Importance in growth advantage	Fusion ? BRAF	Fusion <? BRAF

^aIncluding latent cases.

?: still not clear