Table 1.
Some of the significant proteins involved in pathways known to be implicated in obesity and/or neuronal loss, such as glucose homeostasis, mitochondrial respiration, ion channels and neurotransmission.
| Protein accession number | Protein name | P-value | Fold change (HFD/SD) | Fold change (HGD/SD) | Function/Biological process |
|---|---|---|---|---|---|
| P53986 | Monocarboxylate transporter 1 | 0.03 | −0.72 | −0.06 | Glucose homeostasis |
| Q9D0F9 | Phosphoglucomutase-1 | 0.01 | 0.08 | −0.64 | Glucose homeostasis |
| Q9CXZ1 | NADH dehydrogenase [ubiquinone] iron-sulphur protein 4 | 0.01 | −0.39 | −0.71 | Mitochondrial respiration |
| Q99LY9 | NADH dehydrogenase [ubiquinone] iron-sulphur protein 5 | 0.01 | −0.4 | −0.47 | Mitochondrial respiration |
| P56393 | Cytochrome c oxidase subunit 7B | 0.02 | −0.66 | −0.91 | Mitochondrial respiration |
| P14094 | Sodium/potassium-transporting ATPase subunit beta-1 | 0.03 | −0.08 | 0.06 | Ion channels |
| P97445 | Voltage-dependent P/Q-type calcium channel subunit alpha-1A | 0.02 | −0.57 | −0.25 | Ion channels |
| Q8BJ42 | Disks large-associated protein 2 | 0.002 | 0.55 | 0.17 | Ion channels |
| P16305-1 | Gamma-aminobutyric acid receptor subunit alpha-6 | 0.03 | −0.84 | −0,56 | Neurotransmitters receptor |
| P35438 | Glutamate receptor ionotropic, NMDA 1 | 0.03 | −1.34 | −0.3 | Neurotransmitters receptor |
| P35803 | Neuronal membrane glycoprotein M6-b | 0.02 | −0.94 | −0.78 | Neurotransmitters receptor |
| Q68EF4 | Metabotropic glutamate receptor | 0.03 | −0.63 | −0.54 | Receptor |
The table is reporting P-values, fold changes (as ratios HFD/SD and HGD/SD) as well as the function/biological process of the listed proteins.