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. 2021 May 5;17:11769343211014167. doi: 10.1177/11769343211014167

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Emerging variations in SL1-SL4 of the 5’UTR: (A) the predicted secondary structure of SL1 through SL4 is shown. The position and identity of emerging variants is denoted by an arrow and a letter, (B) the structures of single SL1 variants are shown. The specific variant is shown in red. The variant ID is given above the structure. The RNAfold calculated minimum free energy structure is presented in the diagram, and its thermodynamic stability is given below. (C) same as in (B), but for the two prevalent combination variants that extend the length of SL1, and (D) thermal denaturation curves of SL1 reference sequence and both combination variants. The ΔH°, ΔS°, ΔG°,³⁷ and T_m values shown are the average and standard deviation of three experiments.