Table 1.
Effect of HS and MOLP supplementation on the log fold change (logFC) of differentially expressed genes (DEGs) in pairwise comparison (HS vs. CON, HSM vs. CON and HSM vs. HS) that encode proteins in allograft rejection pathway
| Gene symbol | HS vs. CON | P-value | HSM vs. CON | P-value | P-value | Gene name/Predicted function | |
|---|---|---|---|---|---|---|---|
| Inflammatory factor | IFNG | 3.97 | < 0.0001 | 0.000223 | Interferon gamma precursor | ||
| IL12B | −3.33 | < 0.0001 | −4.57 | < 0.0001 | Interleukin-12 subunit beta | ||
| IGGC | 1.81 | < 0.0001 | 1.35 | < 0.0001 | Ig gamma chain C region | ||
| CD40LG | 11.16 | 0.004 | 10.92 | 0.004 | CD40 ligand | ||
| PRF1 | −1.01 | < 0.0001 | < 0.0001 | Perforin-1 | |||
| LOC100101600 (granzyme H) | −2.44 | < 0.0001 | −3.02 | < 0.0001 | Granzyme H | ||
| LOC100101600 (granzyme B) | < 0.0001 | Duodenase-1 | |||||
| IL10 | 0.0014 | Interleukin-10 isoform X1 | |||||
| CD86 | −1.72 | 0.0004 | 0.0055 | T-lymphocyte activation antigen CD86 precursor | |||
|
MHC (major histocompatibility complex) |
RLA-DMB | < 0.0001 | Histocompatibility antigen DM heterodimer light chain-like precursor | ||||
| LOC100351416 | −1.18 | < 0.0001 | < 0.0001 | HLA class II histocompatibility antigen, DO beta chain isoform X2 | |||
| LOC100351163 | 1.44 | < 0.0001 | < 0.0001 | HLA class II histocompatibility antigen, DQ beta 1 chain isoform X2 | |||
| LOC100343144 | 1.12 | < 0.0001 | < 0.0001 | SLA class II histocompatibility antigen, DQ haplotype D alpha chain isoform X2 | |||
| RLA-DRB1 | < 0.0001 | HLA class II histocompatibility antigen, DRB1–4 beta chain | |||||
| LOC100349667 | −1.12 | 0.021 | HLA class II histocompatibility antigen, DRB1–1 beta chain isoform X1 | ||||
| RLA-A3 | < 0.0001 | MHC class I antigen-like isoform X1 | |||||
| LOC100349247 | −1.36 | < 0.0001 | < 0.0001 | HLA class I histocompatibility antigen, B-7 alpha chain isoform X1 | |||
| LOC100328967 | < 0.0001 | RLA class I histocompatibility antigen, alpha chain 19–1 precursor | |||||
| LOC100349085 | −1.97 | < 0.0001 | < 0.0001 | RLA class I histocompatibility antigen, alpha chain 11/11 | |||
| LOC100338822 | 1.83 | < 0.0001 | 1.38 | < 0.0001 | RLA class I histocompatibility antigen, alpha chain 11/11 |
It may be noted that in pairwise comparison, first group (e.g. in HS vs. CON comparison, the HS group) represents the up- or down-regulated DEGs as compared to other group when logFC value is positive or negative respectively