TABLE 2.
Parameter estimates of final model and bootstrap validation.
| Parameter | Estimate | SE | Bootstrap | Bias (%) | |
|---|---|---|---|---|---|
| Median | 95% Confidence interval | ||||
| CL/F (L/h) | 8.59 | 0.251 | 8.58 | [4.16, 11.30] | −0.12 |
| V/F (L) | 294 | 0.806 | 292 | [58, 973] | −0.85 |
| Ka (h−1) | 0.485 (fixed) | — | — | — | — |
| θOXC | 1.16 | 0.062 | 1.15 | [1.03, 1.34] | −0.86 |
| ωCL/F | 0.175 | 0.232 | 0.162 | [0.095, 0.246] | −7.43 |
| σ1 | 1.913 | 0.065 | 1.895 | [1.640, 2.161] | −0.94 |
95% confidential interval was displayed as the 2.5th, 97.5th percentile of bootstrap estimates. CL/F, apparent oral clearance (L/h); V/F, apparent volume of distribution (L); Ka, absorption rate constant (h−1); θOXC was the coefficient of oxcarbazepine; ωCL/F, inter-individual variability of CL/F; σ1, residual variability, additive error; bias, prediction error, bias = (median-estimate)/estimate × 100%.