Table 5.

Observed number of exposed cases (obs.) among Danish women (N=198 888) and odds ratios (OR) with 95% confidence intervals (CI) by age group and estrogen receptor (ER) status, and various dimensions and time windows of exposure relating to diesel exhaust.

	<50 years								≥50 years
	ER-				ER+				ER-				ER+
Obs.	OR a	95% CI	P-value	Obs.	OR a	95% CI	P-value	Obs.	OR a	95% CI	P-value	Obs.	OR a	95% CI	P-value
Overall exposure	243	1.26	1.09–1.46		634	1.05	0.96–1.15		203	1.16	0.99–1.36		971	1.07	1.00–1.15
Exposure duration (years)
1–9	202	1.25	1.07–1.47		508	1.02	0.92–1.13		171	1.26	1.06–1.50		779	1.13	1.04–1.23
10–20	30	1.20	0.80–1.80		97	1.27	1.01–1.59		20	0.77	0.47–1.21		118	0.83	0.68–1.01
>20	11	1.60	0.81–3.15		29	1.00	0.67–1.50		12	0.89	0.48–1.65		74	0.97	0.75–1.25
Trend test				<0.00				0.07				0.52				0.34
Cumulative exposure (%) b
>0–25	50	1.12	0.82–1.52		138	0.95	0.79–1.14		62	1.53	1.15–2.04		238	1.14	0.99–1.32
>25–50	60	1.21	0.90–1.61		141	1.00	0.83–1.20		48	1.07	0.78–1.46		251	1.08	0.94–1.24
>50–75	65	1.34	1.01–1.77		173	1.06	0.90–1.25		54	1.18	0.87–1.59		242	1.03	0.90–1.19
>75	68	1.36	1.04–1.79		182	1.18	1.00–1.39		39	0.88	0.62–1.24		240	1.04	0.90–1.20
Trend test (P–value)				<0.00				0.02				0.58				0.09
Latency (years) c
<10	58	1.33	0.99–1.79		115	1.00	0.82–1.22		20	1.06	0.65–1.72		97	1.06	0.85–1.32
10–20	85	1.03	0.81–1.31		217	1.04	0.90–1.21		34	1.15	0.79–1.68		145	1.02	0.85–1.22
>20	100	1.49	1.19–1.88		302	1.08	0.95–1.22		149	1.17	0.97–1.41		729	1.09	1.00–1.18
Timing of exposure d
Before first live birth	110	1.11	0.89–1.37		341	1.07	0.95–1.22		63	1.01	0.76–1.34		364	1.12	1.00–1.26
After first live birth	94	1.39	1.09–1.76		210	1.00	0.86–1.16		110	1.10	0.89–1.36		472	0.98	0.89–1.09

^aAdjusted for parity, age at first live birth and work-related physical activity.

^bProbability*intensity*years summed over all exposed time periods in all exposed jobs and categorized according to the percentiles among the controls.

^cYears between first exposure and diagnosis.

^dAmong parous women.