Table 3.
Distribution of Genotypes and Allele Frequencies for EPHX1 His139Arg (rs2234922A>G) Polymorphism in Ischemic Stroke Patients and Controls
| Both Males and Females | Stroke Patients (n=237) |
Controls (n=120) |
OR (95% CI) | P |
|---|---|---|---|---|
| Genotype, n (%) | ||||
| AA (139His/139His) | 163 (68.8) | 79 (65.8) | 0.875a (0.549–1.395) | 0.575 |
| AG (139His/139Arg) | 65 (27.4) | 36 (30) | ||
| GG (139Arg/139Arg) | 9 (3.8) | 5 (4.2) | ||
| Allele frequency | ||||
| A (139His) | 0.825 | 0.808 | 0.895b (0.601–1.335) | 0.587 |
| G (139Arg) | 0.175 | 0.192 | ||
| Males | Male Stroke Patients (n=138) | Male Controls (n=56) | ||
| Genotype, n (%) | ||||
| AA (139His/139His) | 90 (65.2) | 36 (64.3) | 0.960a (0.502–1.837) | 1.000 |
| AG (139His/139Arg) | 41 (29.7) | 16 (28.6) | ||
| GG (139Arg/139Arg) | 7 (5.1) | 4 (7.1) | ||
| Allele frequency | ||||
| A (139His) | 0.801 | 0.786 | 0.913b (0.532–1.565) | 0.739 |
| G (139Arg) | 0.199 | 0.214 | ||
| Females | Female Stroke Patients (n=99) | Female Controls (n=64) | ||
| Genotype, n (%) | ||||
| AA (139His/139His) | 73 (73.7) | 43 (67.2) | 0.729a (0.367–1.450) | 0.367 |
| AG (139His/139Arg) | 24 (24.2) | 20 (31.3) | ||
| GG (139Arg/139Arg) | 2 (2.0) | 1 (1.6) | ||
| Allele frequency | ||||
| A (139His) | 0.859 | 0.828 | 0.794b (0.432–1.459) | 0.456 |
| G (139Arg) | 0.141 | 0.172 |
Notes: Genotype and allele frequencies in male and female populations are also shown separately. aGG+AG vs AA; bG vs A. The OR, CI and P values were calculated using Pearson’s chi-squared test.
Abbreviations: A, adenine; G, guanine.