Table 3.

Spike/ACE2 binding (%) in the presence of punicalagin, ellagic acid, and gallic acid, at concentrations corresponding to those present in 0.04 mg/mL of PPE and equal to 7.29, 0.43, and 0.04 μg/mL, respectively.

Sample	Binding (%)	SD	p-value
Spike/ACE2	100	±10
Spike/ACE2 + PPE	51	±11	0.04
Spike/ACE2 + Punicalagin	36	±4	0.01
Spike/ACE2 + Gallic acid	100	±2	0.5
Spike/ACE2 + Ellagic acid	64	±10	0.03

The results are the averages of three independent experiments, expressed as percentage respect to control arbitrarily set as 100%. ACE2, angiotensin-converting enzyme 2; PPE, pomegranate peels extract.