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A simplified depiction of basic protocols of SCNT cloning showing monkey as NHP representative. SCNT pioneered a new era in stem cell engineering and cellular medicine by proving that it is possible to reprogram the genome of mature cells to a totipotent stage comparable to embryos. Here, COCs, cumulus oocytes complexes, i.e., immature oocytes; IVC, in vitro culture of cell-cytoplast couplets/embryos; IVM, in vitro maturation; HMC, handmade cloning; LOPU, laparoscopic ovum pick-up
