Fig. 4.

Comparison of 3R and 4R tau isoforms in CA4. a Representative image of 3R, 4R, and AT8 staining found in the hippocampal subfield CA4 across each disease. b Comparative analysis of the relative 3R and 4R tau isoforms density found in each disease. Paired two-way ANOVAs were used within each disease group to determine altered 3R/4R levels. *p < 0.05, **p < 0.01, ***p < 0.001. c, d Pairwise comparison of the c 4R and d 3R tau density between each pathologic group using a Pairwise Wilcoxon Rank Sum Tests. Values are FDR adjusted significance score. Green boxes represent significant values. Yellow Boxes are scores that are trending towards significance