Table 2.
The top 10 known up- and downregulated DEGs for the six (A-F) group comparisons
| Gene symbol | Log2FC | P-value | padj | Encoded protein | Expression |
|---|---|---|---|---|---|
| A) LOW vs HIGH | |||||
| DSCAM | −5.460 | 2.84E-05 | 0.015 | Down Syndrome Cell Adhesion Molecule | down |
| C10orf71 | −5.395 | 7.26E-07 | 0.006 | Chromosome 10 Open Reading Frame 71 | down |
| TMEM63C | −5.120 | 1.42E-05 | 0.015 | Transmembrane Protein 63C | down |
| FAM221A | −4.924 | 6.54E-05 | 0.015 | Family With Sequence Similarity 221 Member A | down |
| ADAM7 | −4.889 | 1.08E-05 | 0.0149 | ADAM Metallopeptidase Domain 7 | down |
| STRC | −4.876 | 7.30E-05 | 0.016 | Stereocilin | down |
| TKTL1 | −4.824 | 6.83E-06 | 0.015 | Transketolase Like 1 | down |
| CYP24A1 | −4.770 | 0.0001 | 0.0167 | Cytochrome P450 Family 24 Subfamily A Member 1 | down |
| MYT1 | −4.708 | 0.0001 | 0.017 | Myelin Transcription Factor 1 | down |
| ARHGEF5 | −4.703 | 1.30E-05 | 0.015 | Rho Guanine Nucleotide Exchange Factor 5 | down |
| ETFRF1 | 0.997 | 7.44E-05 | 0.015 | Electron Transfer Flavoprotein Regulatory Factor 1 | up |
| H1–0 | 0.947 | 0.0006 | 0.023 | H1.0 Linker Histone | up |
| CHCHD1 | 0.790 | 0.001 | 0.028 | Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 1 | up |
| PECR | 0.689 | 0.003 | 0.048 | Peroxisomal Trans-2-Enoyl-CoA Reductase | up |
| FBXO6 | 0.685 | 0.001 | 0.027 | F-Box Protein 6 | up |
| ARL2 | 0.642 | 0.003 | 0.044 | ADP Ribosylation Factor Like GTPase 2 | up |
| MRPL20 | 0.625 | 0.0007 | 0.024 | Mitochondrial Ribosomal Protein L20 | up |
| WARS1 | 0.576 | 0.001 | 0.030 | Tryptophanyl-TRNA Synthetase 1 | up |
| PSMB9 | 0.574 | 0.0007 | 0.023 | Proteasome 20S Subunit Beta 9 | up |
| SNAPIN | 0.560 | 0.003 | 0.046 | SNAP Associated Protein | up |
| B) LOW vs NORM | |||||
| CADM1 | −1.234 | 0.0002 | 0.041 | Cell Adhesion Molecule 1 | down |
| CXCR4 | −1.097 | 0.0001 | 0.036 | C-X-C Motif Chemokine Receptor 4 | down |
| VRK2 | −0.678 | 0.0002 | 0.042 | VRK Serine/Threonine Kinase 2 | down |
| GXYLT1 | −0.617 | 0.0003 | 0.043 | Glucoside Xylosyltransferase 1 | down |
| SELENOI | −0.519 | 0.0002 | 0.039 | Selenoprotein I | down |
| TRMT13 | −0.511 | 0.0001 | 0.036 | TRNA Methyltransferase 13 Homolog | down |
| PIKFYVE | −0.419 | 0.0004 | 0.043 | Phosphoinositide Kinase, FYVE-Type Zinc Finger Containing | down |
| FSIP2 | 4.677 | 4.09E-05 | 0.026 | Fibrous Sheath Interacting Protein 2 | up |
| XDH | 4.661 | 7.57E-05 | 0.030 | Xanthine Dehydrogenase | up |
| IQCH | 4.631 | 1.33E-05 | 0.026 | IQ Motif Containing H | up |
| DCST1 | 4.630 | 8.15E-05 | 0.031 | DC-STAMP Domain Containing 1 | up |
| LIPN | 4.557 | 3.09E-05 | 0.026 | Lipase Family Member N | up |
| CSMD3 | 4.452 | 6.03E-05 | 0.027 | CUB And Sushi Multiple Domains 3 | up |
| ABCA12 | 4.450 | 4.66E-05 | 0.026 | ATP Binding Cassette Subfamily A Member 12 | up |
| RNF17 | 4.409 | 3.85E-05 | 0.026 | Ring Finger Protein 17 | up |
| ANO4 | 4.370 | 9.46E-05 | 0.032 | Anoctamin 4 | up |
| CPN1 | 4.323 | 3.01E-05 | 0.026 | Carboxypeptidase N Subunit 1 | up |
| C) PreNxsex | |||||
| TEX11 | −5.219 | 0.0004 | 0.023 | Testis Expressed 11 | down |
| FAT2 | −4.728 | 0.0004 | 0.023 | FAT Atypical Cadherin 2 | down |
| FSIP2 | −4.695 | 0.001 | 0.034 | Fibrous Sheath Interacting Protein 2 | down |
| CCDC180 | −4.534 | 0.002 | 0.042 | Coiled-Coil Domain Containing 180 | down |
| ROBO3 | −4.324 | 0.0005 | 0.024 | Roundabout Guidance Receptor 3 | down |
| LIPN | −4.319 | 8.00E-05 | 0.018 | Lipase Family Member N | down |
| ABCA12 | −4.286 | 0.0001 | 0.018 | ATP Binding Cassette Subfamily A Member 12 | down |
| CNTNAP5 | −4.220 | 0.002 | 0.042 | Contactin Associated Protein Family Member 5 | down |
| CSMD3 | −4.194 | 0.0001 | 0.018 | CUB And Sushi Multiple Domains 3 | down |
| SLC26A5 | −4.157 | 0.0001 | 0.018 | Solute Carrier Family 26 Member 5 | down |
| ANKS4B | 1.046 | 0.0007 | 0.029 | Ankyrin Repeat And Sterile Alpha Motif Domain Containing 4B | up |
| EPHA2 | 0.880 | 0.0002 | 0.019 | EPH Receptor A2 | up |
| PTMA | 0.820 | 0.0002 | 0.020 | Prothymosin Alpha | up |
| BTBD19 | 0.767 | 0.0002 | 0.019 | BTB Domain Containing 19 | up |
| EGR2 | 0.660 | 0.001 | 0.036 | Early Growth Response 2 | up |
| FBRS | 0.630 | 0.0001 | 0.018 | FAU Ubiquitin Like And Ribosomal Protein S30 Fusion | up |
| MAPK8IP3 | 0.588 | 0.0006 | 0.026 | Mitogen-Activated Protein Kinase 8 Interacting Protein 3 | up |
| PLEKHG2 | 0.568 | 0.001 | 0.036 | Pleckstrin Homology And RhoGEF Domain Containing G2 | up |
| SYNDIG1L | 0.567 | 0.0003 | 0.021 | Synapse Differentiation Inducing 1 Like | up |
| ARSL | 0.560 | 0.0003 | 0.022 | Arylsulfatase L | up |
| D) LOW-HCHF vs NORM-CONV | |||||
| LIPA | −3.246 | 6.49E-05 | 0.040 | Lipase A, Lysosomal Acid Type | down |
| FN1 | −3.124 | 4.58E-06 | 0.021 | Fibronectin 1 | down |
| ITGB2 | −3.094 | 0.0001 | 0.040 | Integrin Subunit Beta 2 | down |
| LGALS3 | −3.054 | 1.21E-05 | 0.031 | Galectin 3 | down |
| MSR1 | −3.035 | 0.0002 | 0.041 | Macrophage Scavenger Receptor 1 | down |
| MS4A8 | − 3.025 | 0.0002 | 0.041 | Membrane Spanning 4-Domains A8 | down |
| LCP1 | − 3.029 | 5.66E-05 | 0.040 | Lymphocyte Cytosolic Protein 1 | down |
| CAPG | −3.020 | 0.0002 | 0.044 | Capping Actin Protein, Gelsolin Like | down |
| CTSZ | −3.011 | 3.40E-05 | 0.040 | Cathepsin Z | down |
| C5AR1 | −2.985 | 0.0002 | 0.040 | Complement C5a Receptor 1 | down |
| FIBIN | 1.384 | 0.0004 | 0.048 | Fin Bud Initiation Factor Homolog | up |
| E) HIGH-HCHF vs NORM-CONV | |||||
| ACHE | −4.150 | 8.08E-05 | 0.033 | Acetylcholinesterase (Cartwright Blood Group) | down |
| ST14 | −3.840 | 0.0003 | 0.038 | ST14 Transmembrane Serine Protease Matriptase | down |
| PADI2 | −3.548 | 0.0002 | 0.036 | Peptidyl Arginine Deiminase 2 | down |
| CRLF2 | −3.385 | 0.0005 | 0.044 | Cytokine Receptor Like Factor 2 | down |
| HTRA4 | −3.358 | 0.0002 | 0.036 | HtrA Serine Peptidase 4 | down |
| CD300E | −3.210 | 0.0004 | 0.040 | CD300e Molecule | down |
| S100A5 | −3.211 | 0.0004 | 0.041 | S100 Calcium Binding Protein A5 | down |
| NLRP1 | −3.117 | 4.80E-05 | 0.033 | NLR Family Pyrin Domain Containing 1 | down |
| HK3 | −3.100 | 0.0001 | 0.033 | Hexokinase 3 | down |
| ITGAX | −3.084 | 0.0004 | 0.040 | Integrin Subunit Alpha X | down |
| FIBIN | 1.380 | 0.0004 | 0.040 | Fin Bud Initiation Factor Homolog | up |
| HMCN1 | 1.269 | 0.0003 | 0.038 | Hemicentin 1 | up |
| ETNPPL | 0.990 | 0.0006 | 0.047 | Ethanolamine-Phosphate Phospho-Lyase | up |
| ARHGAP20 | 0.837 | 0.0006 | 0.047 | Rho GTPase Activating Protein 20 | up |
| DHRS12 | 0.780 | 0.0006 | 0.047 | Dehydrogenase/Reductase 12 | up |
| LYRM1 | 0.740 | 0.0006 | 0.047 | LYR Motif Containing 1 | up |
| TRIM13 | 0.593 | 0.0004 | 0.041 | Tripartite Motif Containing 13 | up |
| DNAL1 | 0.589 | 0.0005 | 0.042 | Dynein Axonemal Light Chain 1 | up |
| PDRG1 | 0.564 | 9.18E-05 | 0.033 | P53 And DNA Damage Regulated 1 | up |
| F) HCHF vs CONV | |||||
| SPP1 | −4.788 | 5.45E-05 | 0.021 | Secreted Phosphoprotein 1 | down |
| GPNMB | −4.412 | 2.55E-05 | 0.019 | Glycoprotein Nmb | down |
| TREM2 | −3.924 | 3.08E-05 | 0.019 | Triggering Receptor Expressed On Myeloid Cells 2 | down |
| SCIN | − 3.612 | 2.75E-05 | 0.019 | Scinderin | down |
| LIPA | −3.528 | 3.99E-05 | 0.020 | Lipase A, Lysosomal Acid Type | down |
| CAPG | −3.374 | 4.07E-06 | 0.010 | Capping Actin Protein, Gelsolin Like | down |
| S100A4 | −3.350 | 2.19E-06 | 0.009 | 100 Calcium Binding Protein A4 | down |
| TYROBP | −3.248 | 6.54E-05 | 0.021 | Transmembrane Immune Signaling Adaptor TYROBP | down |
| CTSZ | −3.211 | 1.38E-05 | 0.019 | Cathepsin Z | down |
| MMP9 | −3.170 | 0.0006 | 0.034 | Matrix Metallopeptidase 9 | down |
| LIPN | 5.163 | 3.63E-05 | 0.020 | Lipase Family Member N | up |
| DCST1 | 4.950 | 0.0002 | 0.027 | DC-STAMP Domain Containing 1 | up |
| TEX11 | 4.896 | 1.88E-05 | 0.019 | Testis Expressed 11 | up |
| ABCB5 | 4.823 | 0.0003 | 0.028 | ATP Binding Cassette Subfamily B Member 5 | up |
| CCDC148 | 4.808 | 0.0001 | 0.023 | Coiled-Coil Domain Containing 148 | up |
| FSIP2 | 4.802 | 0.0003 | 0.028 | Fibrous Sheath Interacting Protein 2 | up |
| C6orf58 | 4.796 | 0.0004 | 0.030 | Chromosome 6 Open Reading Frame 58 | up |
| MORC1 | 4.780 | 0.0006 | 0.033 | MORC Family CW-Type Zinc Finger 1 | up |
| DKK1 | 4.776 | 6.43E-05 | 0.021 | Dickkopf WNT Signaling Pathway Inhibitor 1 | up |
| CD28 | 4.642 | 3.12E-06 | 0.010 | CD28 Molecule | up |