Table 3.
The list of top 10 genes identified for six (A-F) group comparisons
| Gene | Degree | Gene | EcCentricity | Gene | EPC | Gene | MNC |
|---|---|---|---|---|---|---|---|
| A) LOW vs HIGH | |||||||
| TTK | 15 | MELK | 0.009771 | TTK | 11.523 | TTK | 14 |
| AURKB | 14 | PBK | 0.009771 | MLPH | 11.41 | AURKB | 13 |
| NDC80 | 13 | ESCO2 | 0.009771 | NDC80 | 11.369 | NDC80 | 13 |
| AURKA | 13 | NDC80 | 0.009771 | AURKA | 11.362 | AURKA | 13 |
| KIF2C | 12 | AURKA | 0.009771 | KIF2C | 11.282 | KIF2C | 12 |
| MELK | 11 | EXO1 | 0.009771 | PBK | 11.094 | MELK | 11 |
| PBK | 11 | POLE | 0.009771 | MELK | 10.921 | PBK | 11 |
| EXO1 | 10 | TTK | 0.009771 | CENPN | 10.474 | CENPN | 9 |
| CCDC39 | 9 | CLSPN | 0.009771 | ASF1B | 9.639 | EXO1 | 8 |
| CENPN | 9 | CCDC39 | 0.007892 | EXO1 | 9.508 | ASF1B | 7 |
| B) LOW vs NORM | |||||||
| CCDC39 | 3 | CCDC39 | 0.024242 | CCDC39 | 2.394 | NIPAL4 | 1 |
| TKTL1 | 2 | TKTL1 | 0.018182 | RIMS2 | 1.932 | RPH3A | 1 |
| RIMS2 | 2 | RIMS2 | 0.018182 | TKTL1 | 1.923 | CCDC39 | 1 |
| NIPAL4 | 1 | NIPAL4 | 0.012121 | HYDIN | 1.912 | HKDC1 | 1 |
| RPH3A | 1 | RPH3A | 0.012121 | DNAH11 | 1.899 | TTN | 1 |
| HKDC1 | 1 | TTN | 0.012121 | ARMC4 | 1.869 | HHIP | 1 |
| TTN | 1 | HHIP | 0.012121 | CNTNAP5 | 1.696 | CNTNAP5 | 1 |
| HHIP | 1 | ROBO3 | 0.012121 | PCLO | 1.68 | ROBO3 | 1 |
| CNTNAP5 | 1 | USH2A | 0.012121 | TEX11 | 1.679 | USH2A | 1 |
| ROBO3 | 1 | ARMC4 | 0.012121 | HKDC1 | 1.666 | TKTL1 | 1 |
| C) CPreNxsex | |||||||
| WDFY1 | 27 | BTAF1 | 0.016998 | CDC5L | 38.608 | ENSOARG00000019688 | 10 |
| ENSOARG00000019688 | 11 | CDC5L | 0.014873 | ENSOARG00000010203 | 35.73 | RSL24D1 | 10 |
| NMD3 | 10 | GTF2B | 0.014873 | RSL24D1 | 34.388 | ENSOARG00000008494 | 9 |
| PRKACB | 10 | CDKN2AIPNL | 0.013221 | ENSOARG00000019688 | 34.338 | SRP54 | 9 |
| SRP54 | 10 | ENSOARG00000010203 | 0.013221 | SRP54 | 34.311 | ENSOARG00000001638 | 9 |
| ENSOARG00000008494 | 9 | TMPO | 0.013221 | ENSOARG00000008494 | 34.285 | ENSOARG00000011629 | 9 |
| ENSOARG00000001638 | 9 | PRPF39 | 0.013221 | ENSOARG00000016333 | 34.274 | ENSOARG00000006781 | 9 |
| ENSOARG00000011629 | 9 | HNRNPC | 0.013221 | RPL37 | 34.25 | LOC780467 | 9 |
| ENSOARG00000006781 | 9 | TCEA1 | 0.013221 | ENSOARG00000001638 | 34.249 | ENSOARG00000016333 | 9 |
| LOC780467 | 9 | MSH6 | 0.013221 | LOC780467 | 34.226 | RPL37 | 8 |
| D) LOW-HCHF vs NORM-CONV | |||||||
| ITGB2 | 11 | CTSS | 0.062706 | ITGB2 | 8.034 | ITGB2 | 10 |
| CTSS | 9 | PTPN6 | 0.062706 | C1QB | 7.933 | CTSS | 9 |
| C1QB | 9 | CSF1R | 0.062706 | CTSS | 7.817 | CSF1R | 8 |
| CSF1R | 8 | ITGB2 | 0.062706 | CSF1R | 7.756 | C1QB | 8 |
| TYROBP | 8 | C5AR1 | 0.04703 | TYROBP | 7.662 | SPI1 | 8 |
| SPI1 | 8 | C1QA | 0.04703 | SPI1 | 7.568 | C1QA | 7 |
| C1QA | 7 | CYBB | 0.04703 | C1QA | 7.427 | TYROBP | 7 |
| LAPTM5 | 7 | LAPTM5 | 0.04703 | LAPTM5 | 7.275 | LAPTM5 | 6 |
| PTPN6 | 4 | FN1 | 0.04703 | PTPN6 | 5.573 | C5AR1 | 3 |
| C5AR1 | 3 | C1QB | 0.04703 | C5AR1 | 5.306 | PTPN6 | 3 |
| E) HIGH-HCHF vs NORM-CONV | |||||||
| ITGB2 | 17 | C1QA | 0.038743 | ITGB2 | 13.878 | ITGB2 | 13 |
| TYROBP | 12 | LAPTM5 | 0.038743 | C1QB | 13.461 | CTSS | 10 |
| CTSS | 11 | CTSS | 0.038743 | TYROBP | 13.449 | C1QB | 10 |
| C1QB | 10 | CSF1R | 0.038743 | CTSS | 13.19 | CSF1R | 9 |
| CSF1R | 9 | C1QC | 0.038743 | CSF1R | 13.163 | TYROBP | 9 |
| SPI1 | 9 | C1QB | 0.038743 | C1QA | 12.963 | SPI1 | 9 |
| C1QA | 8 | ITGB2 | 0.038743 | SPI1 | 12.862 | C1QA | 8 |
| LAPTM5 | 8 | FCER1G | 0.038743 | C1QC | 12.328 | C1QC | 7 |
| C1QC | 7 | TYROBP | 0.03874 | LAPTM5 | 11.808 | LAPTM5 | 6 |
| PTPN6 | 5 | SPI1 | 0.03874 | PTPN6 | 9.368 | C5AR1 | 3 |
| F) HCHF vs CONV | |||||||
| TYROBP | 10 | MMP9 | 0.010243 | TYROB | 13.307 | ATP6V1B2 | 6 |
| CXCR4 | 8 | CD44 | 0.010243 | ITGB | 12.993 | ATP6AP2 | 5 |
| ATP6V1B | 6 | CXCR4 | 0.008536 | CTS | 12.632 | ATP6V1C1 | 5 |
| PTPN | 6 | TGFB1 | 0.008536 | PTPN6 | 12.551 | TCIRG1 | 5 |
| CCDC39 | 6 | CD28 | 0.008536 | CXCR | 12.201 | ATP6V1E1 | 5 |
| PKM | 6 | CYBB | 0.008536 | MMP9 | 12.1 | ATP6V1A | 4 |
| MMP9 | 6 | ALCAM | 0.008536 | LAPTM5 | 11.938 | CTSS | 4 |
| ITGB2 | 6 | ENSOARG0000000780 | 0.008536 | CD44 | 11.692 | MMP9 | 4 |
| TCIRG1 | 6 | SPP1 | 0.008536 | ZAP70 | 11.335 | ITGB2 | 4 |
| ATP6V1A | 5 | ACTN2 | 0.007682 | CYBB | 10.239 | ENTPD5 | 3 |
The top 10 genes were identified according to four different criteria (Degree, EcCentricity, EPC and MNC) through the protein-protein interaction (PPI). Significant hub genes are highlighted in bold