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. 2020 Apr 10;15:159–172. doi: 10.1515/biol-2020-0017

Figure 5.

Figure 5

Overexpression of miR-326 reversed the effects of PCAT6 upregulation in sevoflurane-induced lung cancer cells in vitro. (A) The expression of miR-326 was restored in sevoflurane-administrated cells by transfecting with PCAT6 and miR-326. A serial of physiological assays was conducted to assess the cell viability (B-C), proliferation (D), migration (E) invasion (F), and apoptosis (G) in cells by miR-326 recuperation. (H-I) The protein patterns (c-Myc, MMP-9 and Cleaved-caspase-3) were inverted by miR-326 recuperation in H446 (H) and H1975 (I) cells. (J-K) Wnt5a and β-catenin protein patterns were inverted by miR-326 recuperation in H446 (J) and H1975 (K) cells. *P<0.05. Student’s t-test was performed to compare the difference between two sets of data which came from two groups, and One-way analysis of variance followed by Tukey’s test was employed to compare the differences among multiple groups. P value < 0.05 was regarded as statistically significant.