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Identification of immune cell subsetsa
| UMAP clusters | Subset | Key cluster genes |
|---|---|---|
| B cells and plasma cells | immature | IL7R |
| mature and activated | IGHM, IGHD, IL4R | |
| activated | CD69 | |
| plasma cells | CD27, CD38, JCHAIN | |
| memory | AIM2 | |
| Monocytes and DCs | classical monocytes | CD14 |
| non-classical monocytes | FCGR3A | |
| cDCs (DC2) | high HLA genes and CD74 plus CD1C, FCER1A, CLEC10A (DC2 markers) | |
| pDCs | SERPINF1, LILRA4 |
Note that the immune cell subsets are representative examples and are not meant to be comprehensive.
