Skip to main content
. 2021 May 11;8(4):e997. doi: 10.1212/NXI.0000000000000997

Figure 1. IgA-Coated Bacteria Are Reduced in Patients With Severe MS.

Figure 1

(A) Representative Flow Cytometry Dot Plot Showing Endogenous Secretory IgA Coating on Indicated Fractions of Fecal Microbiota From a Healthy Donor or a Patient With RR-MS (B) Flow cytometry analysis of the fraction of fecal microbiota bound by secretory IgA in healthy donors (n = 32) and patients with RR-MS (n = 32). Median values are indicated, and groups were compared with a nonparametric Mann-Whitney test (ns, not significant). (C) Flow cytometry analysis of the fraction of fecal microbiota bound by secretory IgA in healthy donors (n = 32) and patients with RR-MS classified according to disease severity, measured by the EDSS. Median values are indicated. Error bars represent minimum and maximum values. p Values were calculated using the nonparametric Mann-Whitney test (*p < 0.05; ***p < 0.001). (D) Disease severity evaluated by the EDSS correlated with the percentage of secretory IgA-bound microbiota in patients with MS-RR. Spearman coefficient (r) and p values are indicated. MS = multiple sclerosis; RR = relapsing-remitting.