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. 2021 May 11;8(4):e997. doi: 10.1212/NXI.0000000000000997

Figure 5. MS Antimicrobiota IgG Signature Measured on Cultivable Bacterial Strains.

Figure 5

(A) Representative flow cytometry analysis of serum IgG binding to F nucleatum. Gray histogram represents isotype control; blue, red, and red dotted lines represent a healthy control, patient with RR-MS, and patient with CIS, respectively. (B) Flow cytometry analysis of serum IgG binding to IgA-unbound bacteria (from left to right: F nucleatum and P oris) in healthy donors (n = 30), patients with RR-MS (=32), and patients with CIS (n = 12). (C) Flow cytometry analysis of serum IgG binding to IgA-bound bacteria (from left to right: A muciniphila and R obeum) in healthy donors (n = 30), patients with RR-MS (=32), and patients with CIS (n = 12). Dark bars represent medians. p Values were calculated by using the nonparametric Mann-Whitney test (*p < 0.05; **p < 0.01; ***p < 0.001); ****p < 0.0001). MS = multiple sclerosis; RR = relapsing-remitting.