. Author manuscript; available in PMC: 2022 Mar 1.

Published in final edited form as: Adv Ther (Weinh). 2020 Dec 16;4(3):2000163. doi: 10.1002/adtp.202000163

Table 1.

Plasma TAF and TFV half-lives and PBMC TFV-DP elimination rate constant pharmacokinetics in nTAF washout NHPs.

Analyte	NHP PrEP 5	NHP PrEP 6	NHP PrEP 7	Average	Standard deviation
Plasma TAF t_1/2 (days)	<2.24	<1.71	<1.67	<1.87	±0.32
Plasma TFV t_1/2 (days)	<2.55	<1.61	<1.35	<1.84	±0.63
PBMC TFV-DP k10 (1/day)	0.18	0.13	0.13	0.14	±0.028