Figure 6.

AS rats demonstrate an increased susceptibility to hyperthermia-induced seizures. A, Representative examples of hippocampal EEG at P10–P11 during baseline and hyperthermia induction (FS). Hyperthermia-induced seizures are characterized by high-amplitude, high-frequency burst events (lower two traces: FS-WT, FS-AS). B, Example of EEG-implanted pup prepared for simultaneously evaluation of EEG activity, temperature, and behavior. C, Mean temperature for behavioral onset of hyperthermia-induced seizures is lower for AS compared with WT rats tested at P10–P11 (n = 5–10; p < 0.05).