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. 2021 May 12;11:10134. doi: 10.1038/s41598-021-89631-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Concentrations of active S1P and relative expression of miR-506 in serum. (a) Circulating concentration of sphingosine-1-phosphate (S1P) in serum of PSC and PSC + UC patients in whom colonic tissue were analyzed. (b) Serum concentration of S1P in controls, non-cirrhotic PSC and in PSC patients with liver cirrhosis. (c) The relative expression of miR-506 in sera of PSC and PSC + UC patients. Data were compared with the Fisher’s (PLSD) test and p-values below 0.05 were considered statistically significant. Bars indicate the mean ± standard error (SE).