Table 2.

MiRNAs as potential biomarkers and their clinical significance.

MiRNA	Heart tissue	Circulating blood	Clinical significance
miR-34a-5p	Upregulated in mice	Not tested	✧ Superior to cTnT ✧ Positively related to DOX dose
miR-150-5p	Downregulated in mice	Not tested
miR-133a-3p/miR-133b-3p	Not tested	Upregulated in mice & patients	✧ Possible due to skeletal muscle injury ✧ No difference between cardiotoxic and non-cardiotoxic patients
miR-1-3p	Not tested	Upregulated in patients downregulated in mice	✧ Superior to cTnI ✧ Correlated with LVEF changes
miR-29b-3p	Downregulated in mice	Upregulated in patients	✧ Higher in patients with acute elevated cTnT
miR-29c-3p	Not tested	Upregulated in patients	✧ Initiation of anthracycline
miR-499-5p	Downregulated in mice	Upregulated in patients downregulated in mice	✧ Higher in patients with acute elevated cTnT ✧ Positively correlated to decline in LVEF from initiation to completion of anthracycline
miR-208a-3p	Downregulated in mice	No changes in patients
miR-208b-3p	Upregulated in mice	No changes in patients