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. 2020 Sep 24;31(4):450–462. doi: 10.1038/s41422-020-00411-7

Fig. 7. Lrp6 gene therapy reduced scar formation in the hearts of the mice with MI, and LRP6 knockdown increased mitosis in human iPSC-CMs.

Fig. 7

a Masson’s trichrome serial sections 6 weeks after MI. Analysis of left ventricle scar size and quantification of fibrotic area relative to myocardium in trichrome-stained sections revealed a significant decrease in scar formation in AAV9-miRNAi-Lrp6 hearts. Scale bar = 2 mm. n = 3 mice per group. b EdU incorporation increased significantly following AAV9-miRNAi-Lrp6 treatment of CMs at the border zone. Scale bar = 100 μm. n = 9 mice. c Confocal images show increased mitosis of human iPSC-CMs following LRP6-knockdown. Graph shows the numbers of Aurora B+cTnT+ CMs. Scale bar  = 10 μm. The results represent three experiments. *P < 0.05, **P < 0.01, ***P < 0.001. Data are presented as means ± SD.