Table 2.
Histopathologic features of the IgG4-positive and IgG4-negative idiopathic orbital inflammatory disease.
| IgG4-positive (n = 100) | IgG4-negative (n = 65) | Total (n = 165) | p value | |
|---|---|---|---|---|
| Background fibrosis [n (%)] | ||||
| Type | ||||
| Collagen | 80 (80.0%) | 52 (80.0%) | 132 (80.0%) | 0.202 |
| Storiform | 0 (0) | 0 (0) | 0 (0) | |
| Collagen+storiform | 17 (17.0%) | 13 (20.0%) | 30 (18.2%) | |
| Score | ||||
| 0–1 | 71 (71.0%) | 39 (60.0%) | 110 (66.7%) | 0.143 |
| 2–3 | 29 (29.0%) | 26 (40.0%) | 55 (33.3%) | |
| Lymphocytic infiltrate [n (%)] | ||||
| Score | ||||
| 0–1 | 13 (13.0%) | 25 (38.5%) | 38 (23.0%) | <0.001 |
| 2–3 | 87 (87.0%) | 40 (61.5%) | 127 (77.0%) | |
| Plasmacytic infiltrate [n (%)] | ||||
| Type | ||||
| Nodular | 85 (85.0%) | 35 (53.8%) | 120 (72.7%) | <0.001 |
| Diffuse | 15 (15.0%) | 29 (44.6%) | 44 (26.7%) | |
| Score | ||||
| 0–1 | 31 (31.0%) | 38 (58.5%) | 69 (41.8%) | <0.001 |
| 2–3 | 69 (69.0%) | 27 (41.5%) | 96 (58.2%) | |
| Eosinophilic infiltrate [n (%)] | ||||
| Score | ||||
| 0–1 | 73 (73.0%) | 54 (83.1%) | 127 (77.0%) | 0.133 |
| 2–3 | 27 (27.0%) | 11 (16.9%) | 38 (23.0%) | |
| Follicular hyperplasia [n (%)] | ||||
| Score | ||||
| 0–1 | 34 (34.0%) | 45 (69.2%) | 79 (47.9%) | <0.001 |
| 2–3 | 66 (66.0%) | 20 (30.8%) | 86 (52.1%) | |
| Ki-67a | 15.02 ± 6.86 | 10.83 ± 5.03 | 13.37 ± 6.52 | <0.001 |
p values < 0.05 are in bold.
an = 164.