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. 2021 Apr 28;9:650067. doi: 10.3389/fcell.2021.650067

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Copyright © 2021 Song, Han, Wu, Wang, Zhou, Yang, Liu, Sui, Cai, Ji and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of β-arrestin1 in CRC tissues and its association with the prognosis of patients with CRC. (A–C) Analysis of β-arrestin1 expression profile using data from the GSE41258 dataset. (D) Association between β-arrestin1 expression and the prognosis of patients with CRC. (E) Network representation of β-arrestin1 interactions with multiple genes, including Twist, Snail, CDH1, Vimentin, MMP2, MMP9, GSK-3β, MAPK, etc. (F–G) Immunohistochemical and quantitative analysis of β-arrestin1 protein in representative CRC and metastatic lung/liver tissues (scale bars, upper row: 200 μm, down row: 50 μm, respectively). *P < 0.05; **P < 0.01 vs. Primary tumor.