TABLE 1.
Baseline characteristics, comparing between who developed Scedosporium isolation versus no Scedosporium isolation (n = 19 023)
|
Scedosporium (n = 615) |
No Scedosporium (n = 18 408) |
P-value | |
|---|---|---|---|
| Demographics | |||
| Age (years ± sd) | 22.9 ± 12.3 | 21.1 ± 11.8 | 0.001 |
| Female | 333 (54.2) | 8907 (48.4) | 0.01 |
| White race | 594 (96.6) | 17254 (93.7) | 0.004 |
| F508del homozygous | 300 (48.8) | 8553 (46.5) | 0.16 |
| BMI for adults (kg/m2 ± sd) | 21.6 ± 3.62 | 22.6 ± 3.98 | <0.001 |
| BMI percentile for children (% ± sd) | 43.4 ± 24.5 | 49.6 ± 26.1 | <0.001 |
| Disease characteristics | |||
| Baseline FEV1 % predicted (% ± sd) | 71.4 ± 22.9 | 77.2 ± 25.7 | <0.001 |
| Pancreatic insufficiency | 557 (90.6) | 16131 (87.6) | 0.03 |
| CFRD | 149 (24.2) | 3683 (20.0) | 0.01 |
| ABPA | 63 (10.2) | 1083 (5.9) | <0.001 |
| Medications | |||
| Inhaled antibiotics | 490 (79.7) | 11304 (61.4) | <0.001 |
| Macrolide | 404 (65.7) | 10434 (56.7) | <0.001 |
| Inhaled corticosteroid | 376 (61.1) | 10 765 (58.5) | 0.19 |
| IV antibiotic courses during study period (number ± sd) | 4.13 ± 4.17 | 2.64 ± 3.53 | <0.001 |
| IV antibiotic courses during baseline year (number ± sd) | 1.36 ± 1.63 | 0.90 ± 1.41 | <0.001 |
| Microorganisms | |||
| Pseudomonas aeruginosa | 424 (68.9) | 10 776 (58.5) | <0.001 |
| MRSA | 163 (26.5) | 5236 (28.4) | 0.29 |
| Burkholderia cepacia complex | 20 (3.3) | 567 (3.1) | 0.81 |
BMI, body mass index; FEV1, forced expiratory volume in 1 second; CFRD, Cystic fibrosis related diabetes; ABPA, allergic bronchopulmonary aspergillosis; IV, intravenous; MRSA, methicillin resistant Staphylococcus aureus; sd, standard deviation.