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. 2021 Apr 27;12:667343. doi: 10.3389/fimmu.2021.667343

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Copyright © 2021 Sen and Imlay

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The damage caused to [4Fe-4S]²⁺ cluster enzymes by hydrogen peroxide. The catalytic Fe atom of the dehydratase enzyme reacts with H₂O₂ and dissociates, leaving behind an inactive [3Fe-4S]⁺ cluster. That cluster can be reactivated by reduction and remetallation. In some dehydratases the cluster completely disintegrates to form an apoenzyme. OxyR induces the Suf system to rebuild a functional holoenzyme.